CLINICAL SIGNIFICANCE OF SERUM CA242 AND CEA IN PATIENTS WITH PULMONARY CARCINOMA

Objective:To explore the clinical significance of CA242 and CEA in lung cancer diagnosis,prognosis and estimation of surgical effect.Methods:Using enzyme linded immunosorbent assay(ELISA),the serum levels of CEA and CA242 in patients with lung cancer,benign disease and in normal control were determinated respectively.Results:①Serum concentrations of CA242 and CEA were significantly higher in patients with lung cancer than in patients with benign disease and normal control;②Within patients with lung cancer,serum concentration of CA242 and CEA were higher in stage Ⅲ than in stagen Ⅰ and stage Ⅱ,and higher in adenocarcinoma than in squamous cancer;③The use of CEA and CA242 in combination increased the sensitivity of lung cancer diagnosis;④The preoperative and postoperative levels of serum CA242 and CEA were significantly different.Conclusion:①CA242 and CEA can be used in diagnosis of lung cancer,the expressions of two markers are positively correlated with P TNM stage;②The two tumor markers are best expressed in adenocarcinoma;③Combination of CA242 and CEA can increase sensitivity of measurement;④Postoperative serum concentrations of CEA and CA242 reduces obviously,this testifies that the expression of the two markers is correlated with tumor burden,so it can imply the surgical effect and prognosis.