Follow-up study on influence of metabolism by risperidone and chlorpromazine

Objective:To explore the impact of chlorpromazine,risperidone treatment on the blood glucose and fat level and body weigh in schizophrenia patients. Method:198 schizophrenia patients were enrolled in the study.They were randomly admitted to risperidone therapy group and chlorpromazine therapy group.They are followed up one year.Data of the blood glucose and blood fat and body weight were collected at different point in the one year course of the study. Results:Both cholorpromazine group and risperidone group increased significantly in the index of total cholesterol(TC),triglyceride(TG),fasting blood glucose(FPG),glycated hemoglobin(HbA1c),body weight and body mass index(BMI) while chlorpromazine group was significantly higher in these indexes. Conclusion:While chlorpromazine and risperidone can affect the blood glucose,blood fat and body weight in different ways,but they can both elevated the blood glucose,blood fat level and body weight.