Observation on Curative Effect and Safety of Treatment with Varied Dosage of Simvastatin for Coronary Heart Disease Combined with Hyperlipemia

Objective To observe the curative effect and side effect on treatment with varied dosage of simvastatin for coronary heart disease combined with hyperlipemia.Methods 138 cases of such patient were divided into three groups A,B,C of 46 cases per each.40 mg simvastatin was given in group A,20 mg in group B and 80 mg in group C.The changes of TC,LDLC,TG HDL-C,ALT,BUN,CR and CK were observed before therapy and at 4,12 weeks after therapy.Results There was significant decreasing in Group C than others though the TC and LDL-C decreasing in all groups after therapy. The HDL-C increased in all groups at 12 weeks after therapy.There was no significant difference in decreasing of TG and side effect.Conclusion The results shown that the curative effect might be correlated with the dosage with no affection on side effect during treatment for CHD combined with hyperlipemia.The safety of large dosage of simvastatin therapy might be better.