2002•Journal of Taishan Medical CollegeRequires access

Study on the protective role of bFGF in hypoxic-ischemic brain damage to neonatal rats

Yin Xian

Abstract

Objective: To explore the protective role of basic fibroblast growth factor(bFGF) in hypoxic ischemic brain damage in neonatal rats Method: Seventy two 7 day old Wistar rats were divided into the three groups: Sham, HIBD+Normal Saline (NS)(control) and HIBD+bFGF(observation) SOD activity, MDA and NO level were measured in 0,24,48,72h after the treatment of bFGF or NS, and the apoptosis of brain cell was examined Results: SOD decreased and MDA ?NO increased in HIBD+NS, but SOD increased and MDA?NO decreased in HIBD+bFGF The number of cell apoptosis in HIBD+bFGF was much fewer than that of HIBD+NS(t=2 89, P0 05) Conclusion: bFGF might be useful to protect brain tissue from damage in hypoxic ischemic reperfusion by resisting free redical, deacresing NO and inhibiting cell apoptosis

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Key concepts: Brain damage, Basic fibroblast growth factor, Apoptosis, Medicine, Saline, Cell damage, Brain Cell, Endocrinology