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The Study on Several Protective Efficacy after Hypoxic Ischemic Brain Damage in The Neonatal Rat

Yu-Kun Han

Abstract

Objective To assess the protective efficacy of Lizhucereb(LZCL), cytidine 5' diphosphocholine (CDPC) and basic fibroblast growth factor(bFGF) after hypoxic ischemic brain damage (HIBD) in neonates. Methods The HIBD models was produced with 7 day old Wistar rats.The HIBD rats was treated with CDPC, LZCL or bFGF respectively. The effect on apoptosis of neurons was observed by terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labelling (TUNEL) staining. Results All three drugs relieved brain edema and brain injury, and decreased apoptosis of neurons. Conclusion The results verified the protective efficacy of three drugs on HIBD.

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Key concepts: TUNEL assay, Brain damage, Terminal deoxynucleotidyl transferase, Apoptosis, Medicine, Basic fibroblast growth factor, Pharmacology, Pathology