Clinical significance of coagulation indexes and D-dimer detection in liver diseases

Objective To investigate the clinical value of prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB) and D-dimer(DD) tests in determining the coagulation status,bleeding risk and prognosis of the patients with liver diseases.Methods The Sysmex CA1500 automated coagulometer was used for the detections on 136 patients with liver diseases and 97 healthy subjects and the related statistical analysis was performed.Results Compared with the healthy control group,PT,APTT and TT in liver cancer and cirrhosis groups were significantly prolonged,FIB was significantly reduced,DD significantly increased,the difference was statistically significant(P0.01).PT and APTT in common hepatitis group were prolonged with statistical difference(P0.05).The difference in TT,FIB,DD had no statistical significance(P0.05).Conclusion The coagulation indexes and DD tests are the more sensitive indexes to distinguish various liver diseases and possess certain clinical reference value to dynamically observe the disease condition and judge prognosis.