The result analysis of detection on a number of coagulation indexes of patients with liver disease

Objective To study the different prothrombin time(PT),partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fib),D-dimer(D-D) and platelet(PLT) levels from 146 patients with liver disease and the relationship with the patient′s condition.Methods 146 patients with liver disease and 40 health control group were detected PT,APTT,TT,Fib,DD and PLT levels.Then we used SPSS14.0 to do the t test of the indicators from the groups.Results The levels of PT,APTT,TT,DD in patient group increased in different degrees,but the levels of Fib,PLT decreased;the result showed significant differences in PT,APTT,TT,Fib,DD,PLT levels of liver disease groups and the control group(P0.05 or P0.01);the result showed significant difference between mild chronic hepatitis and acute hepatitis group;while between severe chronic hepatitis and acute hepatitis group,the PT,APTT,TT,Fib,DD and PLT levels were significantly different(P0.05 or P0.01);compared with the mild chronic hepatitis group,the result showed significant differences except the PT level(P0.05 or P0.01);liver cirrhosis compared with other liver diseases,respectively,there was no difference in TT levels,but significant difference in PT,APTT,TT,Fib,D-D and PLT levels(P0.01).Conclusion The PT,APTT,TT,D-D of each group have the positive correlation with the damage degree of liver cell,which has negative relationship with Fib,PLT.The detection of PT,APTT,TT,Fib,D-D and PLT evaluation and understanding of the extent of liver damage in patients with liver disease during the coagulation of different status are good for the clinical diagnosis and prognosis.