The Effect of Hemoperfusion Combined with Hemodialysis in Patients with Uremia

Objective To observe the effect of hemoperfusion combined with hemodialysis in patients with uremia.Methods Forty uremia patients were treated with hemoperfusion combined with hemodialysis for 2～2.5 h then with single hemodialysis for 1.5～2 h,which was performed again after one day.The blood flow rate was 150～240 ml/min,and dialysate flow 500 ml/min.Anticoagulant was heparin or low molecular weight heparin.The blood urea nitrogen,creatinine,electrolyte,parathyroid hormone(PTH),β_2-miocroglobulin(β_2-MG),blood routine and clinical manifestation were observed before and after the treatment.Results The clinical manifestations were improved in majority of the patients.The blood urea nitrogen,creatinine,phosphorus,potassium,PTH and β_2-MG were decreased significantly after treatment(P0.05).No serious side-effect was observed.Conclusion The treatment of hemoperfusion combined with hemodialysis can clear the middle molecular substance and improve some of clinical manifestations in uremic patients effectively.