Clinical Efficacy of Modified Yin-nourishing,Blood-cooling,Stasis-resolving,and Hemostasis Prescription in Syndrome Differentiation-based Treatment of Henoch-Schnlein Purpura Nephritis in Children:A Report of 37 Cases

Objective To observe the clinical efficacy of modified yin-nourishing,blood-cooling,stasis-resolving,and hemostasis prescription(YBSHP)in the syndrome differentiation-based treatment of HenochSchnlein purpura nephritis(HSPN)in children and its effect on the coagulation function of patients.Methods Sixty-seven children with HSPN were randomly divided into traditional Chinese medicine(TCM)group(n=37)and Western medicine(WM)group(n=30).The TCM group was orally given modified YBSHP,while the WM group received conventional WM treatment.The course of treatment was30 dfor both groups.The treatment outcome and coagulation function were compared between the two groups.Results The TCM group had a significantly better treatment outcome than the WM group(P0.05);there were no significant differences in treatment outcome between the patients in TCM group with different syndromes(P0.05).After treatment,both groups showed significant decreases in platelet count(PLT)and plasma fibrinogen(Fib)(P0.05)but significant increases in clotting time(CT),prothrombin time(PT),activated partial thromboplastin time(APTT)(P0.05);compared with the control group,the treatment group had a significantly higher increase in CT(P0.05)but a significantly lower increase in PT(P0.05);there were no significant differences in the changes in PLT,APTT,and Fib between the two groups(P0.05).Conclusion For children with HSPN,modified YBSHP for syndrome differentiation-based treatment has better clinical efficacy than conventional WM treatment,and the two therapies are comparable in improving coagulation function.