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Optimization of Preparation Techniques of Quercetin Solid Lipid Nanoparticles by Uniform Design

Lingbing Li

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Abstract

Objective To prepare quercetin-loaded solid lipid nanoparticles(QT-SLN).Methods The QT-SLN was prepared by emulsification at a high temperature and solidification at a low temperature.The optimum formu-lation and preparation technique of the QT-SLN were selected by uniform design with the entrapment efficiency as the evaluation parameter.Results The QT-SLN prepared in the optimized formulation was even and regular in appearance with particle diameter o(f203±75)nm and entrapment efficiency of 48.5%.Conclusion The optimized QT-SLN technique is stable and feasible.

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What this paper is about

Objective To prepare quercetin-loaded solid lipid nanoparticles(QT-SLN).Methods The QT-SLN was prepared by emulsification at a high temperature and solidification at a low temperature.The optimum formu-lation and preparation technique of the QT-SLN were selected by uniform design with the entrapment efficiency as the evaluation parameter.Results The QT-SLN prepared in the optimized formulation was even and regular in appearance with particle diameter o(f203±75)nm and entrapment efficiency of 48.5%.Conclusion The optimized QT-SLN technique is stable and feasible.

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Available abstract

Objective To prepare quercetin-loaded solid lipid nanoparticles(QT-SLN).Methods The QT-SLN was prepared by emulsification at a high temperature and solidification at a low temperature.The optimum formu-lation and preparation technique of the QT-SLN were selected by uniform design with the entrapment efficiency as the evaluation parameter.Results The QT-SLN prepared in the optimized formulation was even and regular in appearance with particle diameter o(f203±75)nm and entrapment efficiency of 48.5%.Conclusion The optimized QT-SLN technique is stable and feasible.

Key concepts: Solid lipid nanoparticle, Nanoparticle, Materials science, Particle size, Entrapment, Chromatography, Quercetin, Chemistry

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