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2009•Chinese Journal of Hospital PharmacyRequires access

Application of uniform design for preparation of icariin solid lipid nanoparticles

Yang Wang

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Abstract

OBJECTIVE To optimize the formulation for the preparation of the Icariin solid lipid nanoparticles (Ica-SLN).METHODS The optimal preparation was selected by U9(94) uniform design.Ica-SLN was prepared by high temperature melting-cool solidification method.The comprehensive score of the entrapment efficiency,ratio of loading drug,diameter and the Zeta potential was used as index.RESULTS The entrapment efficiency and the ratio of loading drug of Ica-SLN is (73.5±4.7)% and (2.44±0.16)%,respectively.The average diameter is(108.3±2.7)nm and the Zeta potential was(-46.8±3.5)mV.CONCLUSION The application of the uniform design is useful to achieve a high entrapment efficiency and ratio of loading,and the diameter is great satisfaction.

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OBJECTIVE To optimize the formulation for the preparation of the Icariin solid lipid nanoparticles (Ica-SLN).METHODS The optimal preparation was selected by U9(94) uniform design.Ica-SLN was prepared by high temperature melting-cool solidification method.The comprehensive score of the entrapment efficiency,ratio of loading drug,diameter and the Zeta potential was used as index.RESULTS The entrapment efficiency and the ratio of loading drug of Ica-SLN is (73.5±4.7)% and (2.44±0.16)%,respectively.The average diameter is(108.3±2.7)nm and the Zeta potential was(-46.8±3.5)mV.CONCLUSION The application of the uniform design is useful to achieve a high entrapment efficiency and ratio of loading,and the diameter is great satisfaction.

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Available abstract

OBJECTIVE To optimize the formulation for the preparation of the Icariin solid lipid nanoparticles (Ica-SLN).METHODS The optimal preparation was selected by U9(94) uniform design.Ica-SLN was prepared by high temperature melting-cool solidification method.The comprehensive score of the entrapment efficiency,ratio of loading drug,diameter and the Zeta potential was used as index.RESULTS The entrapment efficiency and the ratio of loading drug of Ica-SLN is (73.5±4.7)% and (2.44±0.16)%,respectively.The average diameter is(108.3±2.7)nm and the Zeta potential was(-46.8±3.5)mV.CONCLUSION The application of the uniform design is useful to achieve a high entrapment efficiency and ratio of loading,and the diameter is great satisfaction.

Key concepts: Icariin, Zeta potential, Solid lipid nanoparticle, Entrapment, Materials science, Nanoparticle, Chromatography, Molar ratio

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