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2008•Anhui Medical and Pharmaceutical JournalRequires access

Preparation process of glucosamine sulfate dispersible tablets

Lei Xiao

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Abstract

Aim To investigate the optimum formulation and preparation process of glucosamine sulfate dispersible tablets.Methods The formula of glucosamine sulfate dispersible tablets was optimized in terms of dissolution percent by orthogonal design test.Results The tablets were prepared by moist granulation method with microcrystalling cellulose(MCC) as diluents,and the polyvinylpolyrrolidone(PVPP) and sodium starch glycolate(CMS-Na) as disintegrant.Conclusion The formula of the dispersible tablets is reasonable,with faster disintegration and more complete dissolution.

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What this paper is about

Aim To investigate the optimum formulation and preparation process of glucosamine sulfate dispersible tablets.Methods The formula of glucosamine sulfate dispersible tablets was optimized in terms of dissolution percent by orthogonal design test.Results The tablets were prepared by moist granulation method with microcrystalling cellulose(MCC) as diluents,and the polyvinylpolyrrolidone(PVPP) and sodium starch glycolate(CMS-Na) as disintegrant.Conclusion The formula of the dispersible tablets is reasonable,with faster disintegration and more complete dissolution.

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Available abstract

Aim To investigate the optimum formulation and preparation process of glucosamine sulfate dispersible tablets.Methods The formula of glucosamine sulfate dispersible tablets was optimized in terms of dissolution percent by orthogonal design test.Results The tablets were prepared by moist granulation method with microcrystalling cellulose(MCC) as diluents,and the polyvinylpolyrrolidone(PVPP) and sodium starch glycolate(CMS-Na) as disintegrant.Conclusion The formula of the dispersible tablets is reasonable,with faster disintegration and more complete dissolution.

Key concepts: Diluent, Granulation, Dissolution, Chemistry, Chromatography, Glucosamine, Sulfate, Cellulose

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