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2008•Chinese Journal of PharmaceuticsRequires access

Preparation process of Wuweixiaoduyin dispersible tablets

Jin Ling-yu

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Abstract

Objective To investigate the optimum formulation and preparation process of Wuweixiaoduyin dispersible tablets.Methods The formula of Wuweixiaoduyin dispersible tablets were optimized in terms of disintegration time and dissolution percent by orthogonal design test.Results The tablets were prepared by moist granulation method with alcohol(95%) as moistening agent, microcrystalling cellulose(MCC) as diluents, and the polyvinylpolyrrolidone(PVPP) and sodium croscarboxymethylcellulose(CCMC-Na) as disintegrant.Conclusion The formula of the dispersible tablets is reasonable, with faster disintegration and more complete dissolution.

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What this paper is about

Objective To investigate the optimum formulation and preparation process of Wuweixiaoduyin dispersible tablets.Methods The formula of Wuweixiaoduyin dispersible tablets were optimized in terms of disintegration time and dissolution percent by orthogonal design test.Results The tablets were prepared by moist granulation method with alcohol(95%) as moistening agent, microcrystalling cellulose(MCC) as diluents, and the polyvinylpolyrrolidone(PVPP) and sodium croscarboxymethylcellulose(CCMC-Na) as disintegrant.Conclusion The formula of the dispersible tablets is reasonable, with faster disintegration and more complete dissolution.

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Available abstract

Objective To investigate the optimum formulation and preparation process of Wuweixiaoduyin dispersible tablets.Methods The formula of Wuweixiaoduyin dispersible tablets were optimized in terms of disintegration time and dissolution percent by orthogonal design test.Results The tablets were prepared by moist granulation method with alcohol(95%) as moistening agent, microcrystalling cellulose(MCC) as diluents, and the polyvinylpolyrrolidone(PVPP) and sodium croscarboxymethylcellulose(CCMC-Na) as disintegrant.Conclusion The formula of the dispersible tablets is reasonable, with faster disintegration and more complete dissolution.

Key concepts: Granulation, Pharmaceutics, Diluent, Dissolution, Chromatography, Microcrystalline cellulose, Cellulose, Sodium carboxymethylcellulose

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