Effects and Safety of Citalopram Combined with Low-dose Risperidone on the Refractory Depression

Objective To explore the effects and safety of low-dose Risperidone together with Citalopram on the treatment-resistant depression. Methods All 100 patients with the refractory depression were randomly divided in to the two groups: Citalopram Risperidone group: taken citalopram 20 (mg/d) plus risperidone 0.5～2.0 (mg/d); Citalopram group : only taken Citalopram alone 20 (mg/d). They were estimated with scales of Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Treatment Emergent Symptom (TESS) . The study lasted 4 weeks. Results (1)There were significant differences on the scores of HAMD and HAMA between the two groups at the endpoint of treatment. (2)Treatment with Citalopram Risperidone produced greater improvement than that of Citalopram alone (P0.05), and the Citalopram Risperidone group also showed different but mild side effects. Conclusion Citalopram together with Risperidone in treatment of refractory depression is a useful and safe method.