Clinical Study on Hypertension in Patient With Obstructive Sleep Apena Hypoventilation Syndrome

Objective To investigate the morbidity of hypertension in patients with obstructive sleep apnea hypoventilation syndrome(OSAHS) and its relationship with the severity of OSAHS.Methods Thirty healthy subjects and 111 men with OSAHS were randomly selected to record polysomnography(PSG) and their blood pressure at the next morning was measured and analyzed.Results SBP and DBP in patients with OSAHS were significantly higher than those of the controls,their hypertension prevalence was 51% and it would gradually increase with the severity of OSAHS.The hypertension incidences of the mild,moderate and severe OSAHS were 26%,37%,and 61% respectively.The case with severe OSAHS showed higher systolic and diastolic BP than those of the mild and moderate cases,and their blood pressure during morning awake was also significantly higher than before sleep.Blood pressure significantly decreased after a month application CPAP.MBP of OSAHS were significantly correlated with age(r=0.41,P0.05) and SaO2min(r=-0.41,P0.05).Conclusions There are different pathophysiological mechanisms in patients with severe OSAHS and OSAHS complicated with hypertension.The hypertension of OSAHS is closely related with hypoxia.And the severity and morbidity of hypertension in OSAHS gradually increase with the severity of the disease.Blood pressure significantly decreases after one month CPAP therapy.