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2004•Zhonghua shiyan waike zazhiRequires access

Expression and implication of cyclooxygenase-2 in bladder transitional cell carcinoma

MA Qing-zhen

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Abstract

Objective To study COX-2 expression in bladder transitional cell carcinoma in order to explore the relationship between the immunohistochemical stainings and biological behavior of bladder cancer.Methods COX-2 expression was detected by immunohistochemical methods (LSAB methods) in 78 samples of bladder transitional cell carcinoma (TCC) and their clinical significance was analyzed.Results The positive rate of COX-2 was 56.41 %; COX-2 was highly positively related to the grade,stage and prognosis (P0.01).Conclusion The abnormal expression of COX-2 in bladder TCC was closed correlated with the grade,stage and the prognosis of tumors.

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What this paper is about

Objective To study COX-2 expression in bladder transitional cell carcinoma in order to explore the relationship between the immunohistochemical stainings and biological behavior of bladder cancer.Methods COX-2 expression was detected by immunohistochemical methods (LSAB methods) in 78 samples of bladder transitional cell carcinoma (TCC) and their clinical significance was analyzed.Results The positive rate of COX-2 was 56.41 %; COX-2 was highly positively related to the grade,stage and prognosis (P0.01).Conclusion The abnormal expression of COX-2 in bladder TCC was closed correlated with the grade,stage and the prognosis of tumors.

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Available abstract

Objective To study COX-2 expression in bladder transitional cell carcinoma in order to explore the relationship between the immunohistochemical stainings and biological behavior of bladder cancer.Methods COX-2 expression was detected by immunohistochemical methods (LSAB methods) in 78 samples of bladder transitional cell carcinoma (TCC) and their clinical significance was analyzed.Results The positive rate of COX-2 was 56.41 %; COX-2 was highly positively related to the grade,stage and prognosis (P0.01).Conclusion The abnormal expression of COX-2 in bladder TCC was closed correlated with the grade,stage and the prognosis of tumors.

Key concepts: Immunohistochemistry, Transitional cell carcinoma, Stage (stratigraphy), Medicine, Cyclooxygenase, Carcinoma, Bladder cancer, Bladder Neoplasm

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