Expression of Cyclooxygenase-2 (COX-2) in Human Transitional Cell Carcinoma of Bladder and Its Relationship with HER-2 and p53

Objective To investigate the expression of COX-2,HER-2 and p53 in human transitional cell carcinoma of the bladder and their possible correlation.Methods SP immunohistochemistry staining was performed to evaluate the expression of COX-2,HER-2 and p53 in 56 cases of transitional cell carcinoma of the bladder and 10 cases of normal bladder mucosa.Results(1)The positive expression ratio of COX-2,HER-2 and p53 was 57.1%(32/56),51.8%(29/56)and 50%(28/56),respectively.The difference between carcinoma group and normal tissues group was statistically significant(P0.05).The expression of all above genes was related to clinic stage and the tumor grade(P0.05).(2)The expression of HER-2 and p53 was significant correlation with the expression of COX-2(P0.05).Conclusion The abnormal expression of COX-2,HER-2 and p53 might play a certain role in course of the occurrence,development of transitional cell carcinoma of the bladder.The over-expression of COX-2 in transitional cell carcinoma of the bladder was correlated with the expression of HER-2 and p53.