Effect of levamlodipine besylate on blood pressure and carotid intima-media thickness and left ventrtcular hypertrophy in hypertensive patients

OBJECTIVE To observe the effect of levamlodipine besylate on blood pressure and carotid intima-media thickness and left ventrtcular hypertrophy in hypertensive patients.METHODS All 160patients with mild to moderate primary hypertension were divided randomly and averagely into two groups(levamlodipine besylate-treated group and nifedipine gits-treated group).Clinical blood pressure test was taken in all patients twice a week in the first two weeks after anti-hypertension therapy,then once a week;the carotid and cardi-ac ultrasonographic test before anti-hypertension therapy and 1year later respectively.RESULTS Both levamlodipine besylate and nife-dipine gits reduced the elevated blood pressure evidently and steadily(P0.01),alleviated increased carotid intima-media thickness and left ventrtcular hypertrophy as well(P0.05)without remarkable differences between the two groups(P0.05).CONCLUSION The therapy with levamlodipine besylate both reduces the elevated blood pressure evidently and steadily,and alleviates increased carotid inti-ma-media thickness and left ventrtcular hypertrophy.