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2001•Chinese Journal of Geriatric Cardiovascular and Cerebrovascular DiseaseRequires access

Association of M235T polymorphism of the angiotensinogen gene with cerebral infarction in old patients

Li Jiang

Open publisher page 3 citations

Abstract

Objective To investigate the association between angiotensinogen (AGT) gene M235T polymorphism and cerebral infarction(CI).Methods AGT gene M235T polymorphism was examined in 75 cases of CI and 48 healthy controls by polymerase chain reaction (PCR) amplification and restriction fragment length polymorphism(RFLP).Results The frequencies of AGT gene T235 allele and 235TT genotype were 0.78 and 0.64 respectively in CI group.Compared with those of the control group ( 0.604 and 0.375 respectively),the difference was statistically significant(χ 2=8.82,P=0.003;χ 2=8.27,P=0.004).After three CI risk factors (blood sugar,blood total cholesterol and age) were adjusted,235TT genotype could still raise the incidence of CI (OR=3.289,P=0.036;OR=2.49,P=0.023).Conclusion 235TT genotype of the AGT gene might be an independent risk factor of CI.

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Objective To investigate the association between angiotensinogen (AGT) gene M235T polymorphism and cerebral infarction(CI).Methods AGT gene M235T polymorphism was examined in 75 cases of CI and 48 healthy controls by polymerase chain reaction (PCR) amplification and restriction fragment length polymorphism(RFLP).Results The frequencies of AGT gene T235 allele and 235TT genotype were 0.78 and 0.64 respectively in CI group.Compared with those of the control group ( 0.604 and 0.375 respectively),the difference was statistically significant(χ 2=8.82,P=0.003;χ 2=8.27,P=0.004).After three CI risk factors (blood sugar,blood total cholesterol and age) were adjusted,235TT genotype could still raise the incidence of CI (OR=3.289,P=0.036;OR=2.49,P=0.023).Conclusion 235TT genotype of the AGT gene might be an independent risk factor of CI.

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Available abstract

Objective To investigate the association between angiotensinogen (AGT) gene M235T polymorphism and cerebral infarction(CI).Methods AGT gene M235T polymorphism was examined in 75 cases of CI and 48 healthy controls by polymerase chain reaction (PCR) amplification and restriction fragment length polymorphism(RFLP).Results The frequencies of AGT gene T235 allele and 235TT genotype were 0.78 and 0.64 respectively in CI group.Compared with those of the control group ( 0.604 and 0.375 respectively),the difference was statistically significant(χ 2=8.82,P=0.003;χ 2=8.27,P=0.004).After three CI risk factors (blood sugar,blood total cholesterol and age) were adjusted,235TT genotype could still raise the incidence of CI (OR=3.289,P=0.036;OR=2.49,P=0.023).Conclusion 235TT genotype of the AGT gene might be an independent risk factor of CI.

Key concepts: Genotype, Medicine, Internal medicine, Gastroenterology, Allele, Restriction fragment length polymorphism, Cerebral infarction, Polymorphism (computer science)

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