Comparision of Efficacies of Radix Astragali and Losartan on Diabetic Nephropathy During Clinical Stage

Objective To compare the efficacies of RA and losartan on diabetic nephropathy during clinical stage 68 patients with diabetic nephropathy during clinical stage who were good controlled in blood glucose,blood pressure in clinical periods,were randomly divided into losartan group( n =24),RA group( n =26) and diabetic nephropathy group( n =18) the treatment course was 8 weeks.Methods .Results ⑴24h urine albumin,uraneprotein,urine β-microglobulin(β-MG) in 24h were all reduced (all P 0.01),glomerular filtration rate(GFR) was increased in lasartan group after treatment,⑵RA treatment significant decreased urine albumin,protein and urine β-MG in 24h(all P 0.01),elevated GFR( P 0.01)its effect was obviously stronger than that of losartan,⑶In diabetic nephropathy control group,these marker have not obviously alteration.Conclusion Radix Astragali is a better efficient treatment agent for diabetic nephropathy in clinical stage