Clinical Effect of High Frequency Oscillation Ventilation in Treatment of Neonatal Meconium Aspiration Syndrome

Objective:To evaluate the efficiency of high frequency oscillatory ventilation(HFOV) in treatment of neonatal meconium aspiration syndrome(MAS).Methods:40 infants with MAS were randomly divided into conventional mandatory ventilation(CMV) group(20 cases) and HFOV group(20 cases).The parameter of FiO2,OI were monitored during 48h after mechanical ventilation.Complications and clinical outcomes were compared.Results:FiO2 in CMV group was declined obviously after 12h,it had significant difference,it was declined obviously after 1h in HFOV group,it had significant difference(P0.05).FiO2 in HFOV group was lower than that in CMV group after 24h,it had significant difference(P0.05).OI of lungs in two groups was both declined.Compared with before ventilation,CMV group was improved significantly after 12h,it had significant difference(P0.05),HFOV group was improved significantly after only 1h,it had significant difference(P0.05).OI in HFOV group was significantly lower than that in CMV group after 12h(P0.05),the occurrence rate of PPHN and ALS was significantly lower in HFOV group than in CMV group,it had significant difference(P0.05).Conclusion:HFOV was safe and effective in treatment of neonatal MAS.It had no obvious side effects on cardiovascular system.The effect was better than CMV.