ScholarLens Back to search
2010•Chinese Journal of MisdiagnosticsRequires access

Immunohistochemical Study on Expression of NFKB in Pituitary Adenoma and Recurrent Pituitary Adenoma

Yue Tao

Open publisher page 0 citations

Abstract

Objective To study the immunohistochemical change of NFKB in pituitary adenoma and recurrent pituitary adenoma,then study their roles in the biological behavior of the tumors.Methods Protein expression of NFKB was examined by SABC immunohistochemical technique in 24 cases of human pituitary adenoma and in 12 cases of recurrent pituitary adenoma and 12 cases of normal brain pituitary tissue.Then the correlation between the expression and the biological behavior of the tumors was comprehensively analyzed.Results The normal brain pituitary tissues did not expresse NFKB,but all tissues of the pituitary adenoma expressed NFKB.The level of this protein in recurrent pituitary adenoma was considerably higher than that in pituitary adenoma(P0.01).Conclusion Expression of NFKB is associated with the maligant progression and it may play a critical role in the recurrence of pituitary adenoma.

About this research paper

What this paper is about

Objective To study the immunohistochemical change of NFKB in pituitary adenoma and recurrent pituitary adenoma,then study their roles in the biological behavior of the tumors.Methods Protein expression of NFKB was examined by SABC immunohistochemical technique in 24 cases of human pituitary adenoma and in 12 cases of recurrent pituitary adenoma and 12 cases of normal brain pituitary tissue.Then the correlation between the expression and the biological behavior of the tumors was comprehensively analyzed.Results The normal brain pituitary tissues did not expresse NFKB,but all tissues of the pituitary adenoma expressed NFKB.The level of this protein in recurrent pituitary adenoma was considerably higher than that in pituitary adenoma(P0.01).Conclusion Expression of NFKB is associated with the maligant progression and it may play a critical role in the recurrence of pituitary adenoma.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the immunohistochemical change of NFKB in pituitary adenoma and recurrent pituitary adenoma,then study their roles in the biological behavior of the tumors.Methods Protein expression of NFKB was examined by SABC immunohistochemical technique in 24 cases of human pituitary adenoma and in 12 cases of recurrent pituitary adenoma and 12 cases of normal brain pituitary tissue.Then the correlation between the expression and the biological behavior of the tumors was comprehensively analyzed.Results The normal brain pituitary tissues did not expresse NFKB,but all tissues of the pituitary adenoma expressed NFKB.The level of this protein in recurrent pituitary adenoma was considerably higher than that in pituitary adenoma(P0.01).Conclusion Expression of NFKB is associated with the maligant progression and it may play a critical role in the recurrence of pituitary adenoma.

Key concepts: Pituitary adenoma, Immunohistochemistry, Medicine, Adenoma, Pathology, Pituitary gland, Internal medicine, Hormone

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Immunohistochemical Study on Expression of NFKB in Pituitary Adenoma and Recurrent Pituitary Adenoma — Research Paper | ScholarLens