Difference of expression level of connective tissue growth factor between pituitary adenoma and aggressive pituitary adenoma

Objective To investigate the relationship between the expression of connective tissue growth factor(CTGF) and aggressive of human pituitary adenom,that provides the theoretical basis for the biological treatment of pituitary adenoma. Methods Quantitative real time PCR( qRT-PCR) and Western blot were used to detecte the expression of CTGF in 16 cases of non-invasive pituitary adenoma and 52 cases of invasive pituitary adenoma(IPA) . Results CTGF expression was found in all cases of invasive pituitary adenomas and noninvasive pituitary adenomas. The expression of CTGF in invasive pituitary adenoma was higher than that of in noninvasive pituitary adenoma(P=0. 01) . Conclusions The expression of CTGF in invasive pituitary adenoma is significantly higher than that of in the noninvasive pituitary adenoma and related with the size of pituitary adenoma.