The Exploration of MiR-26a Expression in Serum and Tumor Tissues of Patients with Pituitary Adenoma

Objective: MiRNA spread all the life body occurrence, development, differentiation and death process. It serves to regulate oncogene role in every stage of tumor, cardiovascular, diabetes and other diseases. The abnormal expression of miRNA in pituitary adenoma, and the influence of pituitary adenoma proliferation, invasion and apoptosis. In this study, the expression changes of miRNA in the family miR-26a in pituitary adenoma tissue and serum, and provide evidence for early diagnosis and therapeutic monitoring of pituitary tumor, in order to better guide the clinical diagnosis and treatment. Methods: Totally, 20 consecutive patients with pituitary adenoma were recruited. The manager was 50.1 years with an age range of 20-74 years. All patients were operated in the department of minimal invasive neurosurgery of our hospital, and were confirmed as pituitary adenoma via postoperative pathology. Tumor tissues and serum were collected and analyzed with Real-time PCR. We use SPSS13.0 software package for statistical analysis and Mann-Whitney U test was used if necessary. Results: Expression of miRNA-26a in pituitary adenomas is 22.30, expression of normal pituitary tissues for23.38,the expression of serum miRNA-26a in patients with pituitary adenomas, the expression amount of 25.04, the normal control group, the expression in serum for 24.95. Conclusion: Increased miR-26a expression was detected in pituitary adenoma tissues(P0.05),whereas in blood samples no significance was found between the two groups(P0.05). The normal expression and serological detection of miRNA-26a miRNA-26a in pituitary adenoma tissues, which provides the important basis for clinical diagnosis to prevent the occurrence and devel- opment of pituitary adenoma.