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EXPRESSION OF p27 AND PROLIFERATING CELL NUCLEAR ANTIGEN IN COLORECTAL CARCINOMA AND ITS IMPLICATION

Peng Ren

Abstract

ObjectiveTo explore the expression of p27 and proliferating cell nuclear antigen(PCNA) in colorectal carcinoma,and its biological implication.MethodsExpression of p27 and PCNA in 50 cases of colorectal carcinoma and 50 cases of normal colorectal tissues were examined by immunohistochemistry.ResultsThe expression of p27 and PCNA showed significant difference(P 0.05 ) between normal and colorectal carcinoma tissues.The expression of p27 and PCNA were correlated with the degree of differentiation,stage and lymphatic metastases.ConclusionThe expression of p27 in colorectal carcinoma was significantly associated with clinicopathological characteristics and it may be an important factor for prognosis of colorectal carcinoma. PCNA is an important marker in reflecting cell proliferation.

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Key concepts: Proliferating cell nuclear antigen, Immunohistochemistry, Colorectal cancer, Pathology, Antigen, Carcinoma, Stage (stratigraphy), Cancer research