Study on scale-up of the fermenter of selenium-enriched aspergillus oryzae

The paper is about the scale-up experiment of Selenium-enriched Aspergillus Oryzae from shake flasks to fermenters.The results show that when Selenium-enriched Aspergillus Oryzae had been the content of selenium in a cell reached its maximum 2.896mg/g when it was cultivated for 32 hours,which had risen more 15% than in shake flask culture;the maximum of dry weight of Aspergillus Oryzae was 9.8g/L.And then,expotional Fed batch was made in accordance with parameters got from the batch fermentation.At the thirtieth hour of fermentation,the content of selenium reached its maximum: 3.3mg/L,which rose 14% as compared with that in the batch fermentation;the maximum of dry weight of Aspergillus Oryzae was 12.6g/L,which rose 28% from the batch fermentation.