Research on Relationship between TCM Syndrome of Breast Fibroadenoma and Expression of Hormone Receptor

Objective:To study the relationship between TCM Syndrome of breast Fibroadenoma and expression of estrogen receptor(ER) and progesterone receptor(PR).Methods: According to the TCM syndrome,156 cases of FA patients were divided into 2 types:76 cases of liver qi stagnation type,80 cases of congealation of phlegm and blood stasis type.Using method of SP immunohistochemistry to detect the expression of ER and PR in FA specimens after operation,analysis the relationgship between two groups.Results: There were statistical difference in age,tumor size,tumor recidivism rate,menstruation between two groups(P0.05);but there were no significant difference in course of disease,numbers of tumor,hyperplasia of mammary glands,age of menarche,induced abortion,breast-feeding situation and positive rates and expression strength of ER and PR between two groups(P0.05).Conclusion: It is very important of the high expression of ER and PR in occurrence and development of FA.It could be used as reference for endocrine therapy,but couldn't be applied as basis for the syndrome differentiation of FA.Becaue the age of patients is younger,the tumor is bigger,and the recidivism rate in congealation of phlegm and blood stasis type group is much higher than that of liver qi stagnation type,the time of treatment should to be extended appropriately.