Relationship between sex hormone levels, ER, PR expression and breast fibroadenoma

Objective To study the changes of sex hormone level,estrogen receptor (ER) and progesterone receptor (PR) expression levels and their significance in fibroadenoma ofbreast.Methods The study objects were divided into fibroadenoma group and normal group.Chemiluminescence method was used to detect the luteal phase serum estrogen (E2),progesterone (P),prolactin (PRL) levels,and immunohistochemistry was used to detect ER,PR levels in fibroadenoma group.Results The level of E2 in fibroadenoma group was significantly higher than that in normal group,there was significant difference between the two groups (P ＜ 0.05).There were no significant differences in P and PRL levels between the two groups (P ＞ 0.05).The positive rate ER in fibroadenoma group was 94.7％,the positive rate of PR was 69.3％,and the differences were statistically significant for ER positive intensity between the two groups (P ＜ 0.05).Conclusions The elevated levels of E2 and high expression levels of ER are the main reasons of breast fibroadenoma,which are similar to the causes of hyperplasia of mammry gland.So,active treatment should be given in clinics. Key words: Fibroadenoma of breast;  Sex hormone;  Estrogen receptor;  Progesterone receptor