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Expressions of estrogen receptor, progestogen receptor, androgen receptor in male breast carcinoma and benign lesion

Zhou Bao-sen

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Abstract

OBJECTIVE:To explore the relationship between expressions of estrogen receptor and progestogen receptor, androgen receptor and male breast carcinoma. METHODS: The expressions of ER, PR and AR by immunohistochemistry in 23 cases of male breast carcinomas, and SPSS software was used to analyze the difference in the case and control. RESULTS: The expressions of ER and PR in male breast cancer were 82.6% and 56.5%, being significantly different with benign lesion (OR=4.32 and 5.25, P0.05). AR expression had no relationship with ER and PR. CONCLUSION: The expressions of ER and PR in male breast cancer are lower than those in benign lesion, but AR expression has no relationship with ER and PR.

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OBJECTIVE:To explore the relationship between expressions of estrogen receptor and progestogen receptor, androgen receptor and male breast carcinoma. METHODS: The expressions of ER, PR and AR by immunohistochemistry in 23 cases of male breast carcinomas, and SPSS software was used to analyze the difference in the case and control. RESULTS: The expressions of ER and PR in male breast cancer were 82.6% and 56.5%, being significantly different with benign lesion (OR=4.32 and 5.25, P0.05). AR expression had no relationship with ER and PR. CONCLUSION: The expressions of ER and PR in male breast cancer are lower than those in benign lesion, but AR expression has no relationship with ER and PR.

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Available abstract

OBJECTIVE:To explore the relationship between expressions of estrogen receptor and progestogen receptor, androgen receptor and male breast carcinoma. METHODS: The expressions of ER, PR and AR by immunohistochemistry in 23 cases of male breast carcinomas, and SPSS software was used to analyze the difference in the case and control. RESULTS: The expressions of ER and PR in male breast cancer were 82.6% and 56.5%, being significantly different with benign lesion (OR=4.32 and 5.25, P0.05). AR expression had no relationship with ER and PR. CONCLUSION: The expressions of ER and PR in male breast cancer are lower than those in benign lesion, but AR expression has no relationship with ER and PR.

Key concepts: Androgen receptor, Estrogen receptor, Progestogen, Immunohistochemistry, Breast cancer, Medicine, Breast carcinoma, Estrogen

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