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2003•Zhejiang Medical JournalRequires access

MMP-7 gene expression in gastric cancer and its clinical significance

Zhi Chen

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Abstract

Objective To study the expression of MMP-7 gene in gastric cancer tissue and explore its clinical significance.Methods Reverse transcription polymerase chain reaction (RT-PCR) and dot ELISA was used to detect the expression of MMP-7 mRNA in 35 samples of gastric cancer and the surrounding normal tissue.Results The expression rate of MMP-7 mRNA in 35 gastric cancer samples and the surrounding normal tissue was 60% and 11%, respectively (P0.05).The expression level of MMP-7 gene in gastric cancer was much higher than that in the surrounding normal tissues [ (0.627±0.276) vs (0.237±0.12), P0.05]. Furthermore, the extremely high expression level of MMP-7 mRNA was detected in tumors with metastasis.Conclusion High expression of MMP-7 mRNA in gastric cancer,especially in that with metastasis indicates that MMP-7 may play a role in tumor invasion and metastasis.

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What this paper is about

Objective To study the expression of MMP-7 gene in gastric cancer tissue and explore its clinical significance.Methods Reverse transcription polymerase chain reaction (RT-PCR) and dot ELISA was used to detect the expression of MMP-7 mRNA in 35 samples of gastric cancer and the surrounding normal tissue.Results The expression rate of MMP-7 mRNA in 35 gastric cancer samples and the surrounding normal tissue was 60% and 11%, respectively (P0.05).The expression level of MMP-7 gene in gastric cancer was much higher than that in the surrounding normal tissues [ (0.627±0.276) vs (0.237±0.12), P0.05]. Furthermore, the extremely high expression level of MMP-7 mRNA was detected in tumors with metastasis.Conclusion High expression of MMP-7 mRNA in gastric cancer,especially in that with metastasis indicates that MMP-7 may play a role in tumor invasion and metastasis.

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Available abstract

Objective To study the expression of MMP-7 gene in gastric cancer tissue and explore its clinical significance.Methods Reverse transcription polymerase chain reaction (RT-PCR) and dot ELISA was used to detect the expression of MMP-7 mRNA in 35 samples of gastric cancer and the surrounding normal tissue.Results The expression rate of MMP-7 mRNA in 35 gastric cancer samples and the surrounding normal tissue was 60% and 11%, respectively (P0.05).The expression level of MMP-7 gene in gastric cancer was much higher than that in the surrounding normal tissues [ (0.627±0.276) vs (0.237±0.12), P0.05]. Furthermore, the extremely high expression level of MMP-7 mRNA was detected in tumors with metastasis.Conclusion High expression of MMP-7 mRNA in gastric cancer,especially in that with metastasis indicates that MMP-7 may play a role in tumor invasion and metastasis.

Key concepts: Medicine, Matrix metalloproteinase, Messenger RNA, Metastasis, Clinical significance, Cancer, Reverse transcription polymerase chain reaction, Gene expression

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