The significance of MMP-2 and MMP-7 protein expression in human gastric carcinoma

Objective To study the significance of MMP-2、MMP7 protein expression and the relationship with invasion、 differentiation and and metastasis in human gastric carcinoma.Methods MMP-2、MMP-7 expression were examined by immunobistochemical S-P staining method in 87 cases of human gastric carcinoma、para-carcinoma and normal tissue.Results MMP-2、MMP-7 were negtive of in the normal tissue,and low expression in para-carcinoma,respectively18.4%、21.8%.The overexpression of MMP-2 、MMP-7protein were found in gastric carcinoma,and the expression was highly related with lymphonode metastasia、differentiation and invasion degree(P0.05).Conclusion MMP-2、MMP-7 were highly expressed in gastric carcinoma,and the expression of MMP-2 was significantly correlated with MMP-7.Expression of MMP-2,MMP-7 is strongly associated with tumour progression、differentiation and and lymphonode metastasis in gastric cancer.Therefore MMP-2 、MMP-7 may be clinically useful as predictor of patients surviva1.