Fragile histidine triad gene and skin cancer

FHIT gene,a member of the histidine triad gene family,encodes a diadenosine AP3A.The gene encompasses the common fragile site FRA3B on chromosome 3,where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene.In fact,aberrant transcripts from this gene have been found in about half of all esophageal,stomach,colon carcinomas.FHIT gene may control the cell cycle,apoptosis induced by tumor play a role in the mechanism of its inactivation is mainly expressed in the promoter region of CPG island methylation,deletion and abnormal transcription.Some studies have shown that the FHIT gene is closely related with the occurrence,development,metastasis and prognosis of the skin cancer.This article is based on the latest progress in relationship between the FHIT gene and skin cancer to make review.