ScholarLens Back to search
2006•Zhongguo xin yao zazhiRequires access

An observation study for olanzapine and clozapine in the treatment of irritability and agitation

Jin Ya-jun

Open publisher page 0 citations

Abstract

Objective: To compare the efficacy and safety of olanzapine with clozapine in the treatment of irritability and agitation. Methods:60 patients with bipolar disorders were randomly 1:1 administered olanzapine (15～30 mg·d-1) or clozapine (150～400 mg·d-1) for 2 weeks. BPRS and TESS were used to measure the efficacy and safety of the therapy. Results: Compared with the baseline, the patients experienced significant improvements in BPRS scores at the end of both 1-and 2-weeks of the therapy. The efficacy rate of olanzapine versus clozapine was 76. 6% versus 72. 4% at the end of two-week course of the therapy (P0. 05). The incidence of adverse events in olanzapine-treated patients was significantly less than in clozapine-treated patients. Conclusion:Olanzapine offered an alternative in the treatment of irritability and agitation.

About this research paper

What this paper is about

Objective: To compare the efficacy and safety of olanzapine with clozapine in the treatment of irritability and agitation. Methods:60 patients with bipolar disorders were randomly 1:1 administered olanzapine (15～30 mg·d-1) or clozapine (150～400 mg·d-1) for 2 weeks. BPRS and TESS were used to measure the efficacy and safety of the therapy. Results: Compared with the baseline, the patients experienced significant improvements in BPRS scores at the end of both 1-and 2-weeks of the therapy. The efficacy rate of olanzapine versus clozapine was 76. 6% versus 72. 4% at the end of two-week course of the therapy (P0. 05). The incidence of adverse events in olanzapine-treated patients was significantly less than in clozapine-treated patients. Conclusion:Olanzapine offered an alternative in the treatment of irritability and agitation.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To compare the efficacy and safety of olanzapine with clozapine in the treatment of irritability and agitation. Methods:60 patients with bipolar disorders were randomly 1:1 administered olanzapine (15～30 mg·d-1) or clozapine (150～400 mg·d-1) for 2 weeks. BPRS and TESS were used to measure the efficacy and safety of the therapy. Results: Compared with the baseline, the patients experienced significant improvements in BPRS scores at the end of both 1-and 2-weeks of the therapy. The efficacy rate of olanzapine versus clozapine was 76. 6% versus 72. 4% at the end of two-week course of the therapy (P0. 05). The incidence of adverse events in olanzapine-treated patients was significantly less than in clozapine-treated patients. Conclusion:Olanzapine offered an alternative in the treatment of irritability and agitation.

Key concepts: Olanzapine, Irritability, Clozapine, Medicine, Brief Psychiatric Rating Scale, Adverse effect, Schizophrenia (object-oriented programming), Anesthesia

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
An observation study for olanzapine and clozapine in the treatment of irritability and agitation — Research Paper | ScholarLens