Effect of percutaneous coronary intervention at different time windows on N-terminal pro-brain natriuretic peptide in patients with acute myocardial infarction

Objective To investigate the effect of percutaneous coronary intervention(PCI) at different time windows on N-terminal pro-brain natriuretic peptide(NT-proBNP) ,left ventricular ejection fraction(LVEF) ,and prognosis in patients with acute myocardial infarction(AMI) .Methods Sixty-five patients with AMI were divided into two groups according to the period from AMI attack to PCI treatment:group A(29 cases,≤12 h) and group B(36 cases,12-24 h) .Incidence and mortality of heart failure,NT-proBNP level,and LVEF were detected and compared.Results Compared with the group B,the incidence and mortality of heart failure in the group A were decreased apparently,but showed no significant difference via variance test(all P 0.05) .Observation comparing NT-proBNP levels revealed no significant difference between group A and B on admission(P0.05) ,whereas at 24 h and on 7th d after PCI,we observed a marked decrease in the group A(all P0.05) .Meanwhile,LVEF in the group A were higher than the group B according to echocardiogram examination on 30th d after AMI attack(P 0.05) .Conclusions PCI is an effective method in the treatment of AMI.The myocardial damage would be slighter and the myocardial performance would be markedly improved if the patients with AMI received PCI earlier.