Studies on Enhancing Effect on Volatile Oil of Herba Asari on the Permeation of Palmatine Hydrochloride in Vitro

Objective:To investigate the enhancing effects on volatile oil of Herba Asari on the permeation of Palmatine Hydrochloride through mouse skin in vitro.Methods:A test of enhancing effect of varying concentrations of volatile oil of Herba Asari on the permeation of Palmatine Hydrochloride was conducted by an improved Franz diffusion cells and compared with Azone,the content of Palmatine Hydrochloride was detected with ultraviolet spectrophotometry.Results:In the varying concentrations of penetration enhancers 5%volatile oil of Herba Asari and 5%Azone had the obvious enhancing effect of the permeation of Palmatine Hydrochloride in Vitro when the saline was used as receptor.The average cumulative doses of skin permeation of Palmatine Hydrochloride(5mg/mL)for 24 hours were 5 276.62 and 5 068.87 μg/cm2 respectively;their rate constants of skin permeation for 6 hours were 219.89 and 221.44μg/cm2·h respectively;and their multiple of anatonosis were 1.0326 and 1.3217 respectively.Conclusion:5%volatile oil of Herba Asari possesed the better effects of enhancement the permeation of Palmatine Hydrochloride in vitro.