Study on Plastics Transdermal Absorption of Berberine Hydrochloride of Complex Prescription Coptis chinensis

Objective To study the effects of azone on the percutaneous of berberine hydrochloride in vitro so as to provide experimental basis for complex prescription Coptis chinensis plastics to choose absorb promoter and control production quality.Methods With the skin of nude mice as the barrier,ZTY intelligence permeation skin tester and detection of HPLC were used to study the effects of coalition utilization of azone and borneol for percutaneous absorption of berberine hydrochloride in vitro.Results The rate constants of berberine hydrochloride were 62.591,52.927 and 60.622 μg·cm-2·h-1 respectively when azone and borned of 0,2%,5% were used together.Conclusion Azone with different concentration and bornel inhibit each other when they are combinedly used.The absorption rate is maximum when azone is 0%.