2007•Zhongguo redai yixueRequires access

Impact of cadmium on cytotoxicity and lipid-peroxidation in NRK rat cells

Liang Jing-tan

Abstract

Objective To investigate the effects of cadmium chloride on cytotoxicity and lipid-peroxidation reaction in NRK cells. Methods Various doses of CdCl2 were added to the culture of NRK cells,then cytotoxicity of CdCl2 was tested with MTT assay.In addition,the concentrations of lactate dehydrogenase(LDH),malondialdehyde(MDA) and superoxide dismutase(SOD) were determined. Results CdCl2 had obvious inhibitory effect on the growth of NRK cell,the levels of LDH and MAD in CdCl2-treated groug were higher than that in control group,but SOD in CdCl2-treated groug were lower than that in control group,the effects of CdCl2 were dose-dependent. Conclusion Cadmium showed some cytotoxicity on NRK cells,and it obvious influence the lipid-peroxidation reaction of NRK cells.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Lactate dehydrogenase, Cytotoxicity, Lipid peroxidation, Cadmium chloride, Malondialdehyde, Superoxide dismutase, Chemistry, Cadmium