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2006•Unpublished venueRequires access

Effect of Cadmium on C 6 Glioma Cells in Culture

Son Young-Woo, Kang-Chang Lee

Open publisher page 1 citations

Abstract

It is demonstrated that cadmium has cytotoxic effect on glial cells, oxygen radicals are involved in cadmium-induced cytotoxicity. However, the toxic mechanism of cadmium is left unknown so far. The purpose of this study was to examine the cytotoxicity of CdCl 2 on C 6 glioma cells. The cytotoxicy was measured by cell viability via XTT assay in C 6 glioma cells. Colorimetric assay such as XTT assay is regarded as a very sensitive screening method for the determination of the cell viability on a lots of chemicals. In this study, CdCl 2 decreased cell viability according to the dose- and time dependent manners after C 6 glioma cells were treated with various concentrations of CdCl 2 for 48 hours. IC 90 and IC 50 values for XTT assay was determined at 5 μM and 55 μM of CdCl 2 , respectively. These results suggest that CdCl 2 has highly cytotoxic effect on C 6 glioma cells by the decrease of cell viability.

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What this paper is about

It is demonstrated that cadmium has cytotoxic effect on glial cells, oxygen radicals are involved in cadmium-induced cytotoxicity. However, the toxic mechanism of cadmium is left unknown so far. The purpose of this study was to examine the cytotoxicity of CdCl 2 on C 6 glioma cells. The cytotoxicy was measured by cell viability via XTT assay in C 6 glioma cells. Colorimetric assay such as XTT assay is regarded as a very sensitive screening method for the determination of the cell viability on a lots of chemicals. In this study, CdCl 2 decreased cell viability according to the dose- and time dependent manners after C 6 glioma cells were treated with various concentrations of CdCl 2 for 48 hours. IC 90 and IC 50 values for XTT assay was determined at 5 μM and 55 μM of CdCl 2 , respectively. These results suggest that CdCl 2 has highly cytotoxic effect on C 6 glioma cells by the decrease of cell viability.

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Available abstract

It is demonstrated that cadmium has cytotoxic effect on glial cells, oxygen radicals are involved in cadmium-induced cytotoxicity. However, the toxic mechanism of cadmium is left unknown so far. The purpose of this study was to examine the cytotoxicity of CdCl 2 on C 6 glioma cells. The cytotoxicy was measured by cell viability via XTT assay in C 6 glioma cells. Colorimetric assay such as XTT assay is regarded as a very sensitive screening method for the determination of the cell viability on a lots of chemicals. In this study, CdCl 2 decreased cell viability according to the dose- and time dependent manners after C 6 glioma cells were treated with various concentrations of CdCl 2 for 48 hours. IC 90 and IC 50 values for XTT assay was determined at 5 μM and 55 μM of CdCl 2 , respectively. These results suggest that CdCl 2 has highly cytotoxic effect on C 6 glioma cells by the decrease of cell viability.

Key concepts: Glioma, Cytotoxicity, Cadmium, Viability assay, Cytotoxic T cell, Chemistry, Molecular biology, Cell culture

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