Clinical significance and changes of serum myocardial enzyme in patients with neonatal hypoxic ischemic encephalopathy

Objective:To investigate the change and its clinical significance of myocardial enzyme in the neonatal hypoxic ischemic encephalopathy(HIE).Methods: 90 cases of asphyxia of newborn were divided into severe asphyxia and mild asphyxia group.All born within 48 hours were collected 3ml venous blood in which serum aminotransferase(AST),actate dehydrogenase(LDH),creatine kinase(CK) and creatine kinase isoenzyme(CK-MB the activity) were detected by Japan Olympus AU-1000 biochemical analyzer.Results: AST,LDH,CK and CK-MB activity changes and neonatal asphyxia were positively correlated,and there was a significant difference(P0.01).Conclusion: AST,LDH,CK and CK-MB activity determination as to determining HIE clinical grading,evaluating HIE brain injury severity and treatment has important clinical significance.