Effect of Ninxintongbi capsule on microcirculation,hemorheology and coagulation function in rats

OBJECTIVE To observe the effects of Ninxintongbi capsule on microcirculation,hemorheology and coagulation function in rats.METHODS(1)The mice were given Adr,the auricle microcirculation of mice was observed before and 8 minutes after drug administration.(2)The rats were fed with Ninxintongbi capsule,after 7 days,the blood-stasis model rats were made by injection of high molecule dextran,then observed the hemorheology index.(3)The rats were fed with Ninxintongbi capsule,after 28 days,then observed the coagulation function.RESULTS(1)Compared with the model group,high and medium doses of Ninxintongbi capsule could decrease the contract ratio of the diameter of artery and vein,reduce ratio of micrangium crossing net(P0.01,P0.05).(2)Compared with the model group,Ninxintongbi capsule could reduce blood viscosity and hematocrit(HCT)(P0.05,P0.01).(3)Compared with the model group,Ninxintongbi capsule could reduce platelet aggregation and prolong plasma thrombin time(TT) P0.05.CONCLUSION The results showed that Ninxintongbi capsule have effects of improving auricle microcirculation,decreasing blood viscosity and thrombosis.