Study on drug resistance newborn of klebsiella pneumoniae

Objective To probe into the drug sensitivity about newborn pneumonia of Klebsiella pneumoniae(Kp) and investigate the positive rate of extended-spectrum β-lactamases(ESBLs) in klebsiella pneumoniae.and provide the evidence of reasonable treatment. Method 71 cases of sputum samples new-born pneumonia ofklebsiella pneumoniae from july2008 to may2009 were collected use BioMerieux VITEK2 Compact to Bacteria identification and drug sensitivity testwere per-formed. At the same time, ESBLs were detected. Results the positive rate of ESBLs in klebsiella pneumoniae was 71.8 %, Kp was 100% sensitive to carbopenems, e.g lmipenen, Meropenen, and 80%～90% to Amikacin and Ciprofloxacin,which were hardly used in newborn recent years. While it was resistant to commonly used Penicillin and Cephalosporin.. ESBLs negative strains had higher drug sensitivity than ESBLs strain.Conclusions Partial klebsiella pneumoniae are ESBLs strains and insensitive to commonly used antibiotics. In order to decrease ESBLs strains, the antibiotics treatment shall be used appropriately and the selection of antibiotics shallbe guided by the results ofdrug sensitivity tests. Key words: Newborn;  Pneumonia;  Klebsiella pneumoniae;  ESBLs