Clinical Observation of Niaoduqing Granules in the Treatment of Early Diabetic Nephropathy

OBJECTIVE:To observe the clinical efficacy of Niaoduqing granules in the treatment of early diabetic nephropathy(DN).METHODS:133 patients with early DN of our hospital were randomized into 2 groups.65 cases of control group were given conventional therapy of western medicine(controlling urine protein by angiotensin Ⅱ receptor antagonists or angiotensin converting enzyme inhibitor).68 cases of treatment group were additionally given Niaoduqing granules 5.0 g 4 times a day on the basis of control group for 24 weeks.The changes of hepatic function index(Ccr,MA,HbA1c,FPG,Cys C),hepatic function index(ALB,ALT,AST,Hb) and blood lipid index(TC,TG) were compared between 2 groups before and after treatment;ADR were also recorded.RESULTS:Total effective rate of treatment group was 83.8%,and that of control group was 60.0%,there was statistical significance between 2 groups(P0.05);Cys C and MA of treatment group decreased significantly after treatment,while Ccr level increased significantly(P0.05 or P0.01);there was no statistical significance in other index between 2 groups before and after treatment(P0.05).No severe ADR was found in 2 groups.CONCLUSIONS:Niaoduqing granules are effective in the treatment of early DN,can significantly reduce Cys C and MA and improve glomerular filtration function with sound safety.