Study on effect of mifepristone on embryonic growth and expression of TGF-β and TNF-α

Objective To explore the effect of mifepristone on embryonic growth and transforming growth factor β( TGF- β) in decidua and villi,and serum tumor necrosis factor α( TNF- α). Methods Ninety pregnant women with voluntary artificial abortion were divided into study group and control group according to the difference in induced abortion before treatment scheme. Pregnant women in study group were administrated with 100 mg mifepristone before induced abortion,and pregnant women in control group had not received mifepristone. The expression of TGF- β1 and TGF- β1 R in decidus and villus of 2 groups was examined by reverse transcription polymerase chain reaction,and serum level of TNF- α was examined by radioimmunoassay. Results The gene expressions of TGF- β1 in decidua and TGF- β1R in study group were 1. 66 ±0. 61 and 1. 54 ± 0. 50 respectively,and they were 1 ± 0. 46 and 0. 89 ± 0. 30 respectively in control group,and the difference was significant( P 0. 05); the difference in expression of TGF- β1 and TGF- β1R in villi between these two groups was not significant( P 0. 05). The serum level of TNF- α in study group before taking mifepristone was 0. 55 ± 0. 10 μg / L,and serum level of TNF- αafter taking the drug was 0. 87 ± 0.14 μg / L,and. their difference was significant( P 0. 05). Conclusion Mifepristone can obviously prevent the growth of embryo,it can raise the serum level of TNF- αthrough down- regulation of decidual TGF- β1 and TGF- β1 R transcription,prompting the immune stimulation and inhibition of disorders from maternal and fetal interface from local to peripheral,resulting in the body of mother and not conductive to the maintenance of fetal rejection of pregnancy.