2011•Tianjin yiyaoRequires access
Expression of HER-2 and Its Association with Angiogenesis in Breast Cancer
Weiguo Xu
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Abstract
Objective:To study the expression of human epidermal growth factor receptor-2 (HER-2) and its association with angiogenesis in breast cancer. Methods:The expressions of HER-2 and the value of microvessel density (MVD) were detected by the method of immunohistochemistry in 98 cases of breast cancer and 56 cases of neighboring noncancerous tissue. Results:The positive rates of HER-2 in breast cancer was higher than that in the neighboring noncancerous tissue (P 0.05). The expression of HER-2 was significantly correlated with lymph node metastasis (P 0.05). The expressions of HER-2 and the value of MVD were significantly higher in poorly differentiated group than those in well-differentiated and moderate-differentiated group (P 0.05). The expression of HER-2 was positively correlated with the tumor size. The expression of HER-2 was higher in Ⅲ-stage group than that of Ⅰ-Ⅱ-stage group. Conclusion: The expression of HER-2 is up regulated, which plays an important role in incidence, development and angiogenesis of breast cancer.