Correlation between serum sex hormones levels,blood lipids levels and perimenopausal symptoms

Objective:To research the correlation between serum sex hormones levels,blood lipids levels and perimenopausal symptoms.Methods:The general condition,perimenopausal quality of life,and Kupperman index(KMI) of 215 women were investigated,then 90 study objects were selected and divided into five groups: control group(20 women),perimenopausal group(17 women),early postmenopausal group(21 women),late postmenopausal group(22 women),and hormone replacement therapy(HRT) group(10 women);the serum levels of estradiol,follicle-stimulating hormone(FSH),testosterone(T),total cholesterol(TC),and triglyceride(TG) were detected and compared,respectively;the perimenopausal symptoms and KMI were compared,and the correlation was analyzed.Results:Compared with control group,the serum levels of estradiol and T in perimenopausal group,early postmenopausal group,and late postmenopausal group decreased significantly(P0.05).KMIs in perimenopausal group,early postmenopausal group,and late postmenopausal group increased gradually,which were statistically significantly higher than that in control group(P0.05).There was a negative correlation between estradiol level and KMI(γ=-0.334,P=0.001),there was a negative correlation between T level and KMI(γ=-0.270,P=0.010),there was a positive correlation between FSH level and KMI(γ=0.504,P=0.000);compared with control group,serum TC and TG levels in perimenopausal group,early postmenopausal group,and late postmenopausal group increased significantly(P0.05),there was a positive correlation between serum TG and KM(γ=0.294,P=0.005),there was a positive correlation between TC and KMI(γ=0.244,P=0.021).Conclusion:Serum estradiol and T levels decrease obviously in postmenopausal women,but serum FSH level increases.There is a negative correlation between KMI and serum estradiol,but KMI is positively correlated with serum FSH.Serum TG and TC levels of postmenopausal women increase significantly,TG and TC levels are positively correlated with KMI.