Expression of S-100A4 and MMP-2 and their significance in gastric cancer

Objective To investigate the expression of S100A4 and MMP-2 and their correlations to invasiveness and metastasis in gastric cancer.Methods Archival tissues from 91 patients with gastric cancer were retrieved.Matched samples including adjacent normal gastric tissues,primary tumor and metastasis lymph node tissues were investigated immunohistochemically.The correlations of S100A4 and MMP-2 protein expression with clinicopathologic factors were were analyzed.Results The positive rates of S100A4 protein in non-neoplastic mucosa,primary tumor and lymph node with metastasis were 12.1%,29.7% and 29.2%,and that of MMP-2 protein in the corresponding tissues were 20.8%,58.2% and 59.7%,respectively.The positive rates of S100A4 and MMP-2 protein in primary tumor were obviously higher than that in adjacent normal gastric tissues(P0.05).S100A4 and MMP-2 expression was positively correlated in gastric cancer(r=0.27,P0.05).Conclusion The expression of S100A4 and MMP-2 is closely related to the invasion of gastric cancer.Combined analyses of S100A4 and MMP-2 could be helpful in the evaluation of the clinicopathologic features and prognosis of patients with gastric cancer.