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EFFECTS OF COMPOUND SOPHORA INJECTION ON SERUM IL-1β AND TNF-α IN RATS WITH RHEUMATOID ARTHRITIS

Yao Jian

Abstract

Objective:To observe the effects of compound sophora injection on serum IL-1β and TNF-α in rats with rheumatoid arthritis,and discuss its mechanism.Methods:Experimental model was induced by type II collagen,the inhibitory effect of injection on rats' paw edema was observed,and serum IL-1β and TNF-α level were determined.Results:Compound sophora injection could inhibit rats' paw edema obviously,and lowered serum IL-1β and TNF-α level of rheumatoid arthritis rats.Conclusion:Compound sophora injection could lower serum IL-1β and TNF-α level which maybe one of the mechanism that compound sophora injection effectively treated rheumatoid arthritis.

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Key concepts: Rheumatoid arthritis, Sophora, Medicine, Pharmacology, Tumor necrosis factor alpha, Arthritis, Edema, Immunology