2002•Journal of Modern RehabilitationRequires access

Investigate cerebral protect effect of the VEGF gene and its receptor Flt-1 after transient cerebral ischemia

Bin Xu

Abstract

Objective To investigate the induction of VEGF gene and his receptor Flt-1 expression after transient focal cerebral ischemia at protein levels in order to clarify the role of VEGF in cerebral ischemia.Method A transient middle cerebral artery (MCA) occlusion model was used.Cellular changes of VEGF and its receptor Flt-1 expression were compared with immunohistochemitry.Result VEGF gene and its receptor Flt-1 expressed in the neurons, glial cells and vascular endothelial.Conclusion VEGF and Flt-1 are upregulated during the early period after transient MCAO in the rat. This indicated that the increasing expression of VEGF and Flt-1 possibly had affection to recover the blood supply in the border region.

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Key concepts: Ischemia, VEGF receptors, Medicine, Receptor, Middle cerebral artery, Downregulation and upregulation, Vascular endothelial growth factor, Gene expression