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2009•Anhui Medical and Pharmaceutical JournalRequires access

Effect of magnesium isoglycyrrhizinate in the treatment of the hepatotoxicity caused by anti-tumor agents in cancer patients

Weidong Feng

Open publisher page 4 citations

Abstract

Aim To explore an effective therapy for medicamentous liver lesion induced by chemotherapy in cancer patients.Methods A total of 56 patients with malignant tumor complicated with medicamentous liver lesion induced by chemotherapy were randomly assigned to receive magnesium isoglycyrrhizinate(treatment group)or diammonium glycyrrhizinate for injection(control group)iv gtt qd for 2 consecutive weeks.Results After the treatment for 2 weeks,levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TB)decreased in both groups(P0.01),but there was no significant difference between two groups(P0.05).The rate of marked improvement(71.43% in treatment group and 42.86% in control group)was a significant difference(P0.05).Conclusion MgIG is effective in the treatment of the hepatotoxicity caused by chemotherapy in patients with malignant tumors.

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What this paper is about

Aim To explore an effective therapy for medicamentous liver lesion induced by chemotherapy in cancer patients.Methods A total of 56 patients with malignant tumor complicated with medicamentous liver lesion induced by chemotherapy were randomly assigned to receive magnesium isoglycyrrhizinate(treatment group)or diammonium glycyrrhizinate for injection(control group)iv gtt qd for 2 consecutive weeks.Results After the treatment for 2 weeks,levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TB)decreased in both groups(P0.01),but there was no significant difference between two groups(P0.05).The rate of marked improvement(71.43% in treatment group and 42.86% in control group)was a significant difference(P0.05).Conclusion MgIG is effective in the treatment of the hepatotoxicity caused by chemotherapy in patients with malignant tumors.

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Available abstract

Aim To explore an effective therapy for medicamentous liver lesion induced by chemotherapy in cancer patients.Methods A total of 56 patients with malignant tumor complicated with medicamentous liver lesion induced by chemotherapy were randomly assigned to receive magnesium isoglycyrrhizinate(treatment group)or diammonium glycyrrhizinate for injection(control group)iv gtt qd for 2 consecutive weeks.Results After the treatment for 2 weeks,levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TB)decreased in both groups(P0.01),but there was no significant difference between two groups(P0.05).The rate of marked improvement(71.43% in treatment group and 42.86% in control group)was a significant difference(P0.05).Conclusion MgIG is effective in the treatment of the hepatotoxicity caused by chemotherapy in patients with malignant tumors.

Key concepts: Medicine, Chemotherapy, Bilirubin, Gastroenterology, Lesion, Alanine aminotransferase, Internal medicine, Liver cancer

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Effect of magnesium isoglycyrrhizinate in the treatment of the hepatotoxicity caused by anti-tumor agents in cancer patients — Research Paper | ScholarLens