2010•Kunming Yike Daxue xuebaoRequires access
Expression of Caudal-Relatedhomeodomain Transcription 2 and Cyclooxygenase-2 in Human Colorectal Neoplasms and its Relation to Metastasis
Yingying Zou
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Abstract
Objective To investigate the roles of caudal-relatedhomeodomain transcription-2(CDX2)and Cyclooxygenase-2(COX2)protein in the carcinogenesis,progression,invasion and metastasis of human colorectal adenocarcinomas and identify its relation with the clinicopathological indices of colorectal adenocarcinoma.Methods CDX2 and COX2 protein were detected by SP-immunohistochemistry in formalin-fixed and paraffin-embeded tissues of 30 colorectal adenoma tissues,35 colorectal adenocarcinoma tissues with no regional lymph nodes metastasis,35 primary colorectal adenocarcinoma tissues with regional lymph nodes metastasis.Re sults The expression of COX2 protein distributed in cytoplasms and cell membranes,it was gradually increased from colorectal adenoma tissues to colorectal adenocarcinoma tissues(P=0.000).From the well differentiated colorectal adenocarcinoma tissues to the poor differentiated tissues the expression of COX2 protein was significantly increased(P =0.009).And the expression of COX2 protein between colorectal adenocarcinoma tissues with no regional lymph nodes metastasis and primary colorectal adenocarcinoma tissues with regional lymph nodes metastasis had significant difference(P =0.035,rs =0.253).The expressions of CDX2 protein distributed in karyon,it was gradually decreased from colorectal adenoma tissues to colorectal adenocarcinoma tissues(P=0.000).From the well differentiated colorectal adenocarcinoma tissues to the poor differentiated tissues the expression of CDX2 protein was significantly decreased(P=0.038).And the expression of CDX2 protein between colorectal adenocarcinoma tissues with no regional lymph nodes metastasis and primary colorectal adenocarcinoma tissues with regional lymph nodes metastasis had significant difference(P =0.048,rs =-0.237).Conclusion The down-regulation of CDX2 protein and the up-regulation of COX2 may play important roles in colorectal carcinogenesis and progression.